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Tomar, Dhanendra
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overview Current Projects: Mitochondrial Ultrastructural Remodeling and Inter-Organelles Crosstalk: We aim to identify the molecular determinants, and signaling events associated with mitochondrial contact sites and mitochondrial membranes architecture. Protein Quality Control: Our research aims to identify the molecular determinants of the mitochondrial protein quality control mechanisms and delineate the associated molecular events that lead to disease onset. Calcium signaling and mitochondrial ionic homeostasis: We aim to identify the new regulators and regulatory events associated with mitochondrial calcium-sensing/flux and their role in animal physiology using protein biochemistry, high-end imaging-based approaches, and genetic manipulations. Cardiac Physiology & Metabolism: We aim to characterize the molecular regulators and events involved in cardiac physiology and metabolism using mouse genetics and physiology-based in vivo methods.
One or more keywords matched the following items that are connected to Tomar, Dhanendra
Item TypeName
Concept MAP Kinase Signaling System
Concept Adaptor Proteins, Signal Transducing
Concept Citric Acid Cycle
Concept Glycogen Synthase Kinase 3
Concept Binding Sites
Concept Intracellular Signaling Peptides and Proteins
Concept Signal Transduction
Concept Calcium Signaling
Concept Gene Silencing
Academic Article SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics.
Academic Article Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model.
Academic Article Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Academic Article Metabolite regulation of the mitochondrial calcium uniporter channel.
Academic Article Novel BAG3 Variants in African American Patients With Cardiomyopathy: Reduced ß-Adrenergic Responsiveness in Excitation-Contraction.
Academic Article Context-Dependent Regulation of Nrf2/ARE Axis on Vascular Cell Function during Hyperglycemic Condition.
Academic Article Nicotinamide riboside kinase-2 alleviates ischemia-induced heart failure through P38 signaling.
Academic Article Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation.
Academic Article MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress.
Academic Article The role of DJ-1 in human primary alveolar type II cell injury induced by e-cigarette aerosol.
Academic Article Cardiomyocyte-GSK-3a promotes mPTP opening and heart failure in mice with chronic pressure overload.
Academic Article Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes.
Academic Article Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals.
Academic Article TRIM8 regulated autophagy modulates the level of cleaved Caspase-3 subunit to inhibit genotoxic stress induced cell death.
Academic Article Egr-1 mediated cardiac miR-99 family expression diverges physiological hypertrophy from pathological hypertrophy.
Academic Article Methylene blue counteracts cyanide cardiotoxicity: cellular mechanisms.
Academic Article Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, ß-adrenergic insensitivity, and increased apoptosis.
Academic Article Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity.
Academic Article hsa-miR-4485 regulates mitochondrial functions and inhibits the tumorigenicity of breast cancer cells.
Academic Article BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes.
Academic Article TRIM4; a novel mitochondrial interacting RING E3 ligase, sensitizes the cells to hydrogen peroxide (H2O2) induced cell death.
Academic Article SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore.
Academic Article NLRX1 acts as tumor suppressor by regulating TNF-a induced apoptosis and metabolism in cancer cells.
Academic Article TRIM family proteins: emerging class of RING E3 ligases as regulator of NF-?B pathway.
Academic Article TRIM13 regulates ubiquitination and turnover of NEMO to suppress TNF induced NF-?B activation.
Academic Article Antiviral signaling protein MITA acts as a tumor suppressor in breast cancer by regulating NF-?B induced cell death.
Academic Article TRIM13 regulates caspase-8 ubiquitination, translocation to autophagosomes and activation during ER stress induced cell death.
Academic Article Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-?B pathway.
Academic Article Mitochondria: one of the destinations of miRNAs.
Academic Article Systematic analysis of small RNAs associated with human mitochondria by deep sequencing: detailed analysis of mitochondrial associated miRNA.
Academic Article The leucine aminopeptidase of Staphylococcus aureus is secreted and contributes to biofilm formation.
Academic Article TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells.
Grant Impact of mitochondrial structure on cellular homeostasis and hepatic injury
Grant Mitochondrial protein quality control and calcium signaling in myocardial ischemia-reperfusion injury
Academic Article Suppression of Ca2+ signaling enhances melanoma progression.
Academic Article MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca2+ uniporter channel.
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